D Holloways Picture

David Holloway


e-mail: phone: fax:
dhollowa@bcit.ca 604-456-8199 604-432-9173

Instructor Office Hours
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Research

David Holloway’s research is focused on how animals and plants achieve their body plans and shapes through spatial chemical patterns. He and collaborators at Stony Brook, New York, are working on how fruit fly embryos determine their head-to-tail axes, and how they position their appendages along this axis. Statistical analysis of protein patterns on the embryos allows them to reconstruct the biochemical reactions underlying how embryos turn out so reproducibly (robustly). Plants are continually growing as protein patterns are laid down, unlike most cases of animal development. The theoretical challenge is to understand how chemical pattern formation operates in a growing system, especially if the chemicals are driving growth. Holloway does computational work to explore this, with the aim of being able to understand, and perhaps control, plant shape in the real world. This work involves collaboration with UBC, the University of Victoria, and Harvard University. As well, BCIT computer students have helped develop graphical-interface Windows software for a distributable package to aid experimental botanists in understanding growth dynamics. This research has been supported by the U.S. National Institutes of Health and the Natural Sciences and Engineering Research Council of Canada. Holloway has a Ph.D. in physical chemistry from UBC (1995).

 


Awards

Math Department

British Columbia Institute of Technology

3700 Willingdon Avenue, Burnaby,

British Columbia, Canada, V5G 3H2,

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